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The appearance of autoantibodies and clinical manifestations of autoimmune disease, including vitiligo, have been associated with statistically significant improvements in overall survival rates for patients with cutaneous melanoma
Timilsina, M., Tandan, M., dAquin, M
10.1016/j.jtemb.2019.03.002 J
HFD inhibits the transcription of key antioxidant genes by triggering NRF2 translocation into obese mouse Tregs nucleus, causing a rapid decline in HO-1 expression in Tregs, leading to enhanced oxidative stress and possible ferroptosis, and causing an intensification of obesity and inflammatory responses (156) ( Figure 3 )
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